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Aberrant somatic L- and T-type calcium channel function in cNurr1 and LRRK2-G2019S mice

2022-11-04

Abstract excerpt

<title>Abstract</title> <p>In Parkinson’s disease (PD), axons of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc) degenerate before their cell bodies. Calcium influx during pacemaker firing is suggested to contribute to neuronal loss, but it is not known if, and at which stage of the disease, dysfunctions of voltage-gated calcium channels (VGCCs) occur in DA neurons somata and axon terminals....

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Literature Corpus work
124784e8-fd0c-530b-a3dc-5ca5ca7d16f3
DOI
10.21203/rs.3.rs-2166496/v1
Open publication

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