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Epilepsy-associated Mutations in the Calcium-sensing Receptor Disrupt the Regulation of NALCN Sodium-leak Channel by Extracellular Calcium in Neurons

2020-11-08

Abstract excerpt

Most mammalian neurons have a resting membrane potential (RMP) of ~ −50 mV to −70 mV, significantly above the equilibrium potential of K + (E K ) of ~ −90 mV. The resting Na + -leak conductance is a major mechanism by which neurons maintain their RMPs above E K . In the hippocampal neurons, the TTX-insensitive, voltage-independent Na + leak is mediated by the NALCN cation channel. Extracellular Ca 2+ (Ca 2+...

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Literature Corpus work
8d21c888-fbbd-5f49-afab-bb338d1accc2
DOI
10.1101/2020.11.07.372623
Open publication

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Epilepsy-associated Mutations in the Calcium-sensing Receptor Disrupt the Regulation of NALCN Sodium-leak Channel by Extracellular Calcium in NeuronsDOI 10.1101/2020.11.07.372623
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