Article

Inhibition of striatal dopamine release by the L-type calcium channel inhibitor isradipine co-varies with risk factors for Parkinson’s

2020-07-04

Abstract excerpt

Ca 2+ entry into nigrostriatal dopamine (DA) neurons and axons via L-type voltage-gated Ca 2+ channels (LTCCs) contributes respectively to pacemaker activity and DA release, and has long been thought to contribute to vulnerability to degeneration in Parkinson’s disease. LTCC function is greater in DA axons and neurons from substantia nigra pars compacta than from ventral tegmental area, but this is not explained...

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Literature Corpus work: 3d3ad379-beb2-5d92-888b-e35a312ab03d
DOI: 10.1101/2020.07.03.186411

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