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Article

Developmental profile of the aberrant dopamine D2 receptor response in striatal cholinergic interneurons in DYT1 dystonia.

PloS one - 1 Jan 2011

Sciamanna Giuseppe, Tassone Annalisa, Martella Giuseppina, Mandolesi Georgia, Puglisi Francesca, Cuomo Dario, Madeo Grazia, Ponterio Giulia, Standaert David George, Bonsi Paola, Pisani Antonio

Abstract excerpt

BACKGROUND: DYT1 dystonia, a severe form of genetically determined human dystonia, exhibits reduced penetrance among carriers and begins usually during adolescence. The reasons for such age dependence and variability remain unclear. METHODS AND RESULTS: We characterized the alterations in D2 dopa...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP-Binding Protein alpha Subunits, Gi-Go

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Share to Receptor, Adenosine A2A

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Source

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Identifiers

PMID: 21912682
DOI: 10.1371/journal.pone.0024261
PMCID: PMC3166312

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21912682-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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