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Article

Compensatory T-type Ca2+ channel activity alters D2-autoreceptor responses of Substantia nigra dopamine neurons from Cav1.3 L-type Ca2+ channel KO mice.

Scientific reports - 18 Sept 2015

Poetschke Christina, Dragicevic Elena, Duda Johanna, Benkert Julia, Dougalis Antonios, DeZio Roberta, Snutch Terrance P, Striessnig Joerg, Liss Birgit

Abstract excerpt

The preferential degeneration of Substantia nigra dopamine midbrain neurons (SN DA) causes the motor-symptoms of Parkinson's disease (PD). Voltage-gated L-type calcium channels (LTCCs), especially the Cav1.3-subtype, generate an activity-related oscillatory Ca(2+) burden in SN DA neurons, contributing to their degeneration and PD. While LTCC-blockers are already in clinical trials as PD-therapy, age-dependent...

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Source

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Identifiers

PMID: 26381090
DOI: 10.1038/srep13688
PMCID: PMC4585382

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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