Article
The Lipase Activity of Phospholipase D2 is Responsible for Nigral Neurodegeneration in a Rat Model of Parkinson's Disease.
Neuroscience - 1 May 2018
Mendez-Gomez Hector R, Singh Jasbir, Meyers Craig, Chen Weijun, Gorbatyuk Oleg S, Muzyczka Nicholas
Abstract excerpt
Phospholipase D2 (PLD2), an enzyme involved in vesicle trafficking and membrane signaling, interacts with α-synuclein, a protein known to contribute in the development of Parkinson disease (PD). We previously reported that PLD2 overexpression in rat substantia nigra pars compacta (SNc) causes a rapid neurodegeneration of dopamine neurons, and that α-synuclein suppresses PLD2-induced nigral degeneration (Gorbatyuk...
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