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Article

ATR promotes cilia signalling: links to developmental impacts

11 Feb 2016

Abstract excerpt

Mutations in ATR(ataxia telangiectasia and RAD3-related) cause Seckel syndrome (ATR-SS), a microcephalic primordial dwarfism disorder. Hitherto, the clinical manifestation of ATR deficiency has been attributed to its canonical role in DNA damage response signalling following replication fork stalling/collapse. Here, we show that ATR regulates cilia-dependent signalling in a manner that can be uncoupled from its...

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PMID: 26908596
DOI: 10.1093/hmg/ddw034

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