The Pathogenic Role of the DNA Double-Stranded Breaks in Hereditary Cardiomyopathies.

Abstract excerpt

Hereditary cardiomyopathies are caused primarily by mutations in genes encoding the protein constituents of cardiac myocytes. The mutation imparts biochemical, mechanical, and metabolic stresses, which not only induce the cardiomyopathy phenotype but also damage the nuclear and mitochondrial DNA, through oxidation, alkylation, cross-linking, and others. The DNA lesions, if unrepaired, cause replication and...

Topics

• Humans
• Cardiomyopathies
• DNA Breaks, Double-Stranded
• DNA Repair
• Mutation
• Myocytes, Cardiac