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Article

A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging.

Nature genetics - 1 Aug 2009

Murga Matilde, Bunting Samuel, Montaña Maria F, Soria Rebeca, Mulero Francisca, Cañamero Marta, Lee Youngsoo, McKinnon Peter J, Nussenzweig Andre, Fernandez-Capetillo Oscar

Abstract excerpt

Although DNA damage is considered a driving force for aging, the nature of the damage that arises endogenously remains unclear. Replicative stress, a source of endogenous DNA damage, is prevented primarily by the ATR kinase. We have developed a mouse model of Seckel syndrome characterized by a se...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19620979
DOI: 10.1038/ng.420
PMCID: PMC2902278

Genes

ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19620979-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging.PMID 19620979Read ↗

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ATRIP protects progenitor cells against DNA damage <i>in vivo</i>Semantic proximity Read ↗

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Ataxia Telangiectasia and Rad3-related protein (ATR) maintains cardiac tissue functionalitySemantic proximity Read ↗

Seckel syndrome exhibits cellular features demonstrating defects in the ATR-signalling pathwaySemantic proximity Read ↗

ATR suppresses endogenous DNA damage and allows completion of homologous recombination repair.Semantic proximity Read ↗

ATR localizes to the photoreceptor connecting cilium and deficiency leads to severe photoreceptor degeneration in mice.Semantic proximity Read ↗

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Small molecule inhibition of p38 MAP kinase extends the replicative life span of human ATR-Seckel syndrome fibroblasts.Semantic proximity Read ↗

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Primary microcephaly, impaired DNA replication, and genomic instability caused by compound heterozygous ATR mutations.Semantic proximity Read ↗

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