Article

The sleep quality- and myopia-linked PDE11A-Y727C variant impacts neural physiology by reducing catalytic activity and altering subcellular compartmentalization of the enzyme

2023-11-17

Abstract excerpt

<h4>ABSTRACT</h4> Recently, a Y727C variant in the dual-specific 3’,5’-cyclic nucleotide phosphodiesterase 11A (PDE11A-Y727C) was linked to increased sleep quality and reduced myopia risk in humans. Given the well-established role that the PDE11 substrates cAMP and cGMP play in eye physiology and sleep, we determined if 1) PDE11A protein is expressed in the retina or other eye segments in mouse, 2) PDE11A-Y7272C...

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Literature Corpus work: 4e63a354-43fa-5d63-9ccc-46f21c84ea59
DOI: 10.1101/2023.11.16.567422

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