Article

Age-related increases in PDE11A4 protein expression trigger liquid:liquid phase separation (LLPS) of the enzyme that can be reversed by PDE11A4 small molecules inhibitors

2024-10-02

Abstract excerpt

<h4>ABSTRACT</h4> PDE11A is a little-studied phosphodiesterase sub-family that breaks down cAMP/cGMP, with the PDE11A4 isoform being enriched in the memory-related brain region called the hippocampus. Age-related increases in PDE11A expression occur in human and rodent hippocampus and cause age-related cognitive decline of social memories. Interestingly, the age-related increase in PDE11A4 protein ectopically acc...

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Literature Corpus work: 8fac675e-d771-5c6f-8e74-0f096245dc77
DOI: 10.1101/2024.10.01.616004

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