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Article

Unexpected proteinopathies in hippocampal PDE11A4 promote age-related cognitive decline of social associative memories

2022-04-10

Abstract excerpt

<h4>ABSTRACT</h4> In humans, associative memories are more susceptible to age-related cognitive decline (ARCD) than are recognition memories. Reduced cAMP/cGMP signaling in the hippocampus may contribute to ARCD. Here, we found that both aging and traumatic brain injury-associated dementia increased expression of the cAMP/cGMP-degrading enzyme phosphodiesterase 11A (PDE11A) in the human hippocampus. Further, age-...

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Literature Corpus work
4e4acb85-634e-5cdb-85c0-83c546781eef
DOI
10.1101/2022.04.08.487696
Open publication

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Unexpected proteinopathies in hippocampal PDE11A4 promote age-related cognitive decline of social associative memoriesDOI 10.1101/2022.04.08.487696
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