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Article

Phosphodiesterases in neurodegenerative disorders

5 Nov 2012

Abstract excerpt

Cyclic nucleotide phosphodiesterases (PDEs) are responsible for the breakdown of cyclic nucleotides, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). As such, they are crucial regulators of levels of cyclic nucleotide-mediated signaling. cAMP signaling and cGMP signaling have been associated with neuroplasticity and protection, and influencing their levels in the cell by inhibition...

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Share to Adenosine and Purinergic Signaling
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PMID: 23129425
DOI: 10.1002/iub.1104

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