Article

Inferring tumour microenvironment ecosystems from scRNA-seq atlases

2024-08-21

Abstract excerpt

Accurate inference of granular cell states that co-occur within the tumour microenvironment (TME) is central to defining pro– and anti-tumour environments. Here, we describe how ecosystems of cell populations can be robustly inferred from nonspatial single-cell RNA-seq (scRNA-seq) atlases. Leveraging a unique discovery-validation setup across eight scRNA-seq datasets profiling pancreatic ductal adenocarcinoma (PDA...

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Literature Corpus work: 11f7c101-26e5-523b-a003-6090c1326bc9
DOI: 10.1101/2024.08.21.608956

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