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Integrative analysis of pan-cancer single-cell data reveals a tumor ecosystem subtype predicting immunotherapy response

14 Sept 2024

Abstract excerpt

Tumor ecosystem shapes cancer biology and potentially influence the response to immunotherapy, but there is a lack of direct clinical evidence. In this study, we utilized EcoTyper and publicly available scRNA-Seq cohorts from ICI-treated patients. We found a ecosystem subtype (ecotype) was linked to improved responses to immunotherapy. Then, a novel immunotherapy-responsive ecotype signature (IRE.Sig) was...

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PMID: 39277681
DOI: 10.1038/s41698-024-00703-w

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