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Single-cell morphological and topological atlas reveals the ecosystem diversity of human breast cancer

25 Oct 2023

Abstract excerpt

Digital pathology allows computerized analysis of tumor ecosystem using whole slide images (WSIs). Here, we present single-cell morphological and topological profiling (sc-MTOP) to characterize tumor ecosystem by extracting the features of nuclear morphology and intercellular spatial relationship for individual cells. We construct a single-cell atlas comprising 410 million cells from 637 breast cancer WSIs and...

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PMID: 37880211
DOI: 10.1038/s41467-023-42504-y

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