Article
Crystal structure of Alzheimer's disease phospholipase D3 provides a molecular basis for understanding its normal and pathological functions.
The FEBS journal - 1 Dec 2024
Ishii Kenta, Hermans Stefan J, Georgopoulou Maria Eleni, Nero Tracy L, Hancock Nancy C, Crespi Gabriela A N, Gorman Michael A, Gooi Jonathan H, Parker Michael W
Abstract excerpt
Human 5'-3' exonuclease PLD3, a member of the phospholipase D family of enzymes, has been validated as a therapeutic target for treating Alzheimer's disease. Here, we have determined the crystal structure of the luminal domain of the enzyme at 2.3 Å resolution, revealing a bilobal structure with a catalytic site located between the lobes. We then compared the structure with published crystal structures of other...
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