Article
Structural and mechanistic insights into disease-associated endolysosomal exonucleases PLD3 and PLD4.
Structure (London, England : 1993) - 6 Jun 2024
Yuan Meng, Peng Linghang, Huang Deli, Gavin Amanda, Luan Fangkun, Tran Jenny, Feng Ziqi, Zhu Xueyong, Matteson Jeanne, Wilson Ian A, Nemazee David
Abstract excerpt
Endolysosomal exonucleases PLD3 and PLD4 (phospholipases D3 and D4) are associated with autoinflammatory and autoimmune diseases. We report structures of these enzymes, and the molecular basis of their catalysis. The structures reveal an intra-chain dimer topology forming a basic active site at the interface. Like other PLD superfamily members, PLD3 and PLD4 carry HxKxxxxD/E motifs and participate in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.