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Article

Regulatory dynamics of 11p13 suggest a role for EHF in modifying CF lung disease severity.

Nucleic acids research - 6 Sept 2017

Stolzenburg Lindsay R, Yang Rui, Kerschner Jenny L, Fossum Sara, Xu Matthew, Hoffmann Andrew, Lamar Kay-Marie, Ghosh Sujana, Wachtel Sarah, Leir Shih-Hsing, Harris Ann

Abstract excerpt

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause cystic fibrosis (CF), but are not good predictors of lung phenotype. Genome-wide association studies (GWAS) previously identified additional genomic sites associated with CF lung disease severity. One of these, at chromosome 11p13, is an intergenic region between Ets homologous factor (EHF) and Apaf-1 interacting protein...

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Source

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Identifiers

PMID: 28549169
DOI: 10.1093/nar/gkx482
PMCID: PMC5587731

Genes

EHF
APIP
CFTR
CTCF
ELF5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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