New insights into the cis-regulation of the CFTR gene in pancreatic cells

Abstract excerpt

<title>Abstract</title> <p>Background Spatial organization of the genome is fundamental for ensuring accurate gene expression. This process depends on the communication between gene promoters and distal <italic>cis</italic>-regulatory elements (CREs), which together make up 8% of the human genome and are supported by the chromatin structure. It is estimated that over 90% of disease-associated variants are locate...

Topics

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• Chromatin
• Clustered Regularly Interspaced Short Palindromic Repeats
• Cystic Fibrosis Research Advances
• Gene Expression Profiling
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Genomics and Chromatin Dynamics
• High-Throughput Nucleotide Sequencing

Identifiers and source

Literature Corpus work

76ec9e33-9a2e-503f-9f1f-70790ccd8938

DOI

10.21203/rs.3.rs-5805969/v1