Article

Griffin: Framework for clinical cancer subtyping from nucleosome profiling of cell-free DNA

2021-09-03

Abstract excerpt

Cell-free DNA (cfDNA) has the potential to inform tumor subtype classification and help guide clinical precision oncology. Here we developed Griffin, a new method for profiling nucleosome protection and accessibility from cfDNA to study the phenotype of tumors using as low as 0.1x coverage whole genome sequencing (WGS) data. Griffin employs a novel GC correction procedure tailored to variable cfDNA fragment sizes,...

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Literature Corpus work: eacf6e21-b12d-5239-bfd0-2f3949b00500
DOI: 10.1101/2021.08.31.21262867

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