Article

Making the most of Clumping and Thresholding for polygenic scores

2019-05-30

Abstract excerpt

Polygenic prediction has the potential to contribute to precision medicine. Clumping and Thresh-olding (C+T) is a widely used method to derive polygenic scores. When using C+T, it is common to test several p-value thresholds to maximize predictive ability of the derived polygenic scores. Along with this p-value threshold, we propose to tune three other hyper-parameters for C+T. We implement an efficient way to der...

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Literature Corpus work: 11d70b16-c62a-5a36-97e7-23de2e850d7e
DOI: 10.1101/653204

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