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Article

Making the Most of Clumping and Thresholding for Polygenic Scores.

American journal of human genetics - 5 Dec 2019

Privé Florian, Vilhjálmsson Bjarni J, Aschard Hugues, Blum Michael G B

Abstract excerpt

Polygenic prediction has the potential to contribute to precision medicine. Clumping and thresholding (C+T) is a widely used method to derive polygenic scores. When using C+T, several p value thresholds are tested to maximize predictive ability of the derived polygenic scores. Along with this p value threshold, we propose to tune three other hyper-parameters for C+T. We implement an efficient way to derive...

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Identifiers

PMID: 31761295
DOI: 10.1016/j.ajhg.2019.11.001
PMCID: PMC6904799

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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