Article
Heat shock factor 1 mediates the longevity conferred by inhibition of TOR and insulin/IGF-1 signaling pathways in C. elegans.
Aging cell - 1 Dec 2013
Seo Keunhee, Choi Eunseok, Lee Dongyeop, Jeong Dae-Eun, Jang Sung Key, Lee Seung-Jae
Abstract excerpt
Target of rapamycin (TOR) signaling is an evolutionarily well-conserved pathway that regulates various physiologic processes, including aging and metabolism. One of the key downstream components of TOR signaling is ribosomal protein S6 kinase (S6K) whose inhibition extends the lifespan of yeast, Caenorhabditis elegans, Drosophila, and mice. Here, we demonstrate that the activation of heat shock factor 1 (HSF-1),...
Topics
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Down-Regulation
- Insulin
- Insulin-Like Growth Factor I
- Longevity
- Mice
- Mutation
- Oxidative Stress
- Peptides