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Article

An In Silico Cardiomyocyte Reveals the Impact of Changes in CaMKII Signalling on Cardiomyocyte Contraction Kinetics in Hypertrophic Cardiomyopathy.

BioMed research international - 1 Jan 2024

Adeniran Ismail, Wadee Hafsa, Degens Hans

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is characterised by asymmetric left ventricular hypertrophy, ventricular arrhythmias, and cardiomyocyte dysfunction that may cause sudden death. HCM is associated with mutations in sarcomeric proteins and is usually transmitted as an autosomal-dominant trait. The aim of this in silico study was to assess the mechanisms that underlie the altered electrophysiological activity,...

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Share to Adenosine Triphosphate
Share to Calcium-Calmodulin-Dependent Protein Kinase Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cardiomyopathy, Hypertrophic

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Identifiers

PMID: 38567164
DOI: 10.1155/2024/6160554
PMCID: PMC10985279

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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