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Article

Proteogenomics of Hypertrophic Cardiomyopathy Reveals Subtype-Specific Therapy.

Circulation research - 31 Jul 2026

Ma Ke, Yang Jie, Guo Hongchang, Li Ping, Li Xiaowei, Dong Zhujun, Zhang Jing, Zhang Congcong, Yang Pengli, Hua Chongpei, Zhu Shuolin, Li Guoqing, Zhang Jianchao, Ding Ningyu, Wang Jizheng, Ma Xin-Liang, Lin Zhuofeng, Dong Jianzeng, Li Yang, Li Yulin

Abstract excerpt

BACKGROUND: Hypertrophic cardiomyopathy (HCM) is a heterogeneous disease with diverse prognosis. The underlying mechanisms remain unknown, resulting in limited risk stratification and therapeutic strategies. This study aimed to elucidate molecular subtypes of HCM through integrated proteogenomic analysis and explore subtype-specific therapeutic strategies. METHODS: We conducted an integrated proteogenomic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42381624
DOI: 10.1161/CIRCRESAHA.126.328300
PMCID: PMC13418873

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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