Article

Signaling network model of cardiomyocyte morphological changes in familial cardiomyopathy

2021-08-28

Abstract excerpt

Familial cardiomyopathy is a precursor of heart failure and sudden cardiac death. Over the past several decades, researchers have discovered numerous gene mutations primarily in sarcomeric and cytoskeletal proteins causing two different disease phenotypes: hypertrophic (HCM) and dilated (DCM) cardiomyopathies. However, molecular mechanisms linking genotype to phenotype remain unclear. Here, we employ a systems app...

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Literature Corpus work: 1736a7fc-16c8-5505-9ddd-47580b423ed3
DOI: 10.1101/2021.08.28.458032

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