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Article

Hypertrophic Cardiomyopathy: A Vicious Cycle Triggered by Sarcomere Mutations and Secondary Disease Hits.

Antioxidants & redox signaling - 1 Aug 2019

Wijnker Paul J M, Sequeira Vasco, Kuster Diederik W D, Velden Jolanda van der

Abstract excerpt

Significance: Hypertrophic cardiomyopathy (HCM) is a cardiac genetic disease characterized by left ventricular hypertrophy, diastolic dysfunction, and myocardial disarray. Disease onset occurs between 20 and 50 years of age, thus affecting patients in the prime of their life. HCM is caused by mutations in sarcomere proteins, the contractile building blocks of the heart. Despite increased knowledge of causal...

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Identifiers

PMID: 29490477
DOI: 10.1089/ars.2017.7236
PMCID: PMC6602117

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