Chronic sleep curtailment expediates brain aging by activating the complement and coagulation cascades in mice

Abstract excerpt

<h4>ABSTRACT</h4> Chronic sleep insufficiency is prevalent in modern society and has been associated with age-related neurodegenerative diseases. Loss of sleep accelerates the progression of neurodegeneration in animal models of neurological diseases. Here, we study whether chronic sleep curtailment leads to brain aging in wild-type animals without a genetic predisposition. We used a wild-type mouse model to simu...

Topics

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• Age Factors
• Amino Acid Metabolism, Inborn Errors
• Ataxin-3
• Behavior, Animal
• Machado-Joseph Disease
• Mice, Transgenic
• Microglia
• Nuclear Proteins

Identifiers and source

Literature Corpus work

11a46af3-9f11-55cf-a3cd-55062d2691eb

DOI

10.1101/2025.02.18.638886