Article
Computational and digital analyses in the INSPIRE mouse cohort to define sex-specific functional determinants of biological aging.
Science advances - 13 Dec 2024
Santin Yohan, Chiesa Mattia, Alfonso Amélie, Doghri Yosra, Kang Ryeonshi, Haidar Fraha, Oreja-Fuentes Pilar, Fousset Occiane, Zahreddine Rana, Guardia Mégane, Lemmel Lucas, Rigamonti Mara, Rosati Giorgio, Florian Cédrick, Gauzin Sébastien, Guyonnet Sophie, Rolland Yves, de Souto Barreto Philipe, Vellas Bruno, Guiard Bruno, Parini Angelo
Abstract excerpt
Biological age, which reflects the physiological state of an individual, offers a better predictive value than chronological age for age-related diseases and mortality. Nonetheless, determining accurate functional features of biological age remains challenging due to the multifactorial nature of aging. Here, we established a unique mouse cohort comprising 1576 male and female outbred SWISS mice subjected or not...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.