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Differential effects of short-term and long-term ketogenic diet on gene expression in the aging mouse brain

10 Dec 2024

Abstract excerpt

BACKGROUND: Aging is associated with multiple neurodegenerative conditions that severely limit quality of life and can shorten lifespan. Studies in rodents indicate that in addition to extending lifespan, the ketogenic diet (KD) improves cognitive function in aged animals, yet long term adherence to KD in Humans is poor. OBJECTIVES: To broadly investigate what mechanisms might be activated in the brain in...

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PMID: 39662156
DOI: 10.1016/j.jnha.2024.100427

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