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HSF1-mediated Proteostasis Decline Links Aging and Sleep Disruption

2026-04-24

Abstract excerpt

Sleep disruption increases with age and is associated with adverse age-related outcomes, yet the molecular mechanisms linking these phenomena remain unclear. Here, through integrative analysis of human and mouse transcriptomic and proteomic datasets, we identify proteostasis-related pathways whose aging trajectories align with transcriptional responses to chronic sleep disruption across tissues and cell types. In...

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Literature Corpus work
13295950-4006-51e9-b7ac-e36da991e0dd
DOI
10.64898/2026.04.21.719983
Open publication

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HSF1-mediated Proteostasis Decline Links Aging and Sleep DisruptionDOI 10.64898/2026.04.21.719983
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