Article

Global C3 lowering in adulthood protects against hippocampal dysfunction and cognitive impairment in aged mice

2025-06-23

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Complement component 3 (C3) is increasingly recognized for its role in neurodegenerative processes; however, its specific impact on age-related hippocampal dysfunction remains poorly understood. This study investigates the effects of inducible C3 knockdown in adulthood on hippocampal function using a novel mouse model. <bold>Methods:</bold> We developed a chimer...

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Literature Corpus work: 7b8d31ce-504f-538c-834c-56484f95d80d
DOI: 10.21203/rs.3.rs-6924607/v1

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