Article

Deficiency of complement component C1Q prevents cerebrovascular damage and white matter loss in a mouse model of chronic obesity

2020-02-03

Abstract excerpt

<h4>ABSTRACT</h4> Age-related cognitive decline and many dementias involve complex interactions of both genetic and environmental risk factors. Recent evidence has demonstrated a strong association of obesity with the development of dementia. Furthermore, white matter damage is found in obese subjects and mouse models of obesity. Here, we found that components of the complement cascade, including C1QA and C3 are...

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Literature Corpus work: 57b58577-6bc3-54dc-89a0-e1f5d9d69f1a
DOI: 10.1101/2020.02.03.931949

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