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Article

Automated behavioral phenotyping reveals presymptomatic alterations in a SCA3 genetrap mouse model.

Journal of genetics and genomics = Yi chuan xue bao - 20 Jun 2012

Hübener Jeannette, Casadei Nicolas, Teismann Peter, Seeliger Mathias W, Björkqvist Maria, von Hörsten Stephan, Riess Olaf, Nguyen Huu Phuc

Abstract excerpt

Characterization of disease models of neurodegenerative disorders requires a systematic and comprehensive phenotyping in a highly standardized manner. Therefore, automated high-resolution behavior test systems such as the homecage based LabMaster system are of particular interest. We demonstrate the power of the automated LabMaster system by discovering previously unrecognized features of a recently characterized...

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Identifiers

PMID: 22749017
DOI: 10.1016/j.jgg.2012.04.009

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