Article

Genomic and phenotypic analyses suggest moderate fitness differences among Zika virus lineages

2022-02-02

Abstract excerpt

RNA viruses have short generation times and high mutation rates, allowing them to undergo rapid molecular evolution during epidemics. However, the extent of RNA virus phenotypic evolution within epidemics and the resulting effects on fitness and virulence remain mostly unknown. Here, we screened the 2015-2016 Zika epidemic in the Americas for lineage-specific fitness differences. We engineered a library of recombi...

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Literature Corpus work: 119e0d58-511c-5aab-ac97-e65cbb7df92a
DOI: 10.1101/2022.02.01.478673

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