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Adaptation to host cell environment during experimental evolution of Zika virus

21 Oct 2022

Abstract excerpt

Zika virus (ZIKV) infection can cause important developmental and neurological defects in Humans. Type I/III interferon responses control ZIKV infection and pathological processes, yet the virus has evolved various mechanisms to defeat these host responses. Here, we established a pipeline to delineate at high-resolution the genetic evolution of ZIKV in a controlled host cell environment. We uncovered that...

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PMID: 36271143
DOI: 10.1038/s42003-022-03902-y

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