Article
Single Amino Acid Mutations Affect Zika Virus Replication In Vitro and Virulence In Vivo.
Viruses - 12 Nov 2020
Collette Nicole M, Lao Victoria H I, Weilhammer Dina R, Zingg Barbara, Cohen Shoshana D, Hwang Mona, Coffey Lark L, Grady Sarah L, Zemla Adam T, Borucki Monica K
Abstract excerpt
The 2014-2016 Zika virus (ZIKV) epidemic in the Americas resulted in large deposits of next-generation sequencing data from clinical samples. This resource was mined to identify emerging mutations and trends in mutations as the outbreak progressed over time. Information on transmission dynamics, prevalence, and persistence of intra-host mutants, and the position of a mutation on a protein were then used to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.