Article
A Zika virus mutation enhances transmission potential and confers escape from protective dengue virus immunity.
Cell reports - 12 Apr 2022
Regla-Nava Jose Angel, Wang Ying-Ting, Fontes-Garfias Camila R, Liu Yang, Syed Thasneem, Susantono Mercylia, Gonzalez Andrew, Viramontes Karla M, Verma Shailendra Kumar, Kim Kenneth, Landeras-Bueno Sara, Huang Chun-Teng, Prigozhin Daniil M, Gleeson Joseph G, Terskikh Alexey V, Shi Pei-Yong, Shresta Sujan
Abstract excerpt
Zika virus (ZIKV) and dengue virus (DENV) are arthropod-borne pathogenic flaviviruses that co-circulate in many countries. To understand some of the pressures that influence ZIKV evolution, we mimic the natural transmission cycle by repeating serial passaging of ZIKV through cultured mosquito cells and either DENV-naive or DENV-immune mice. Compared with wild-type ZIKV, the strains passaged under both conditions...
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