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Article

An accumulated mutation gained in mosquito cells enhances Zika virus virulence and fitness in mice.

Journal of virology - 19 Nov 2024

Fan Xiao-Xuan, Li Rui-Ting, Zhu Yi-Bin, Chen Qi, Li Xiao-Feng, Cao Tian-Shu, Zhao Hui, Cheng Gong, Qin Cheng-Feng

Abstract excerpt

Zika virus (ZIKV) remains a significant public health threat worldwide. A number of adaptive mutations have accumulated within the genome of ZIKV during global transmission, some of which have been linked to specific phenotypes. ZIKV maintains an alternating cycle of replication between mosquitoes and vertebrate hosts, but the role of mosquito-specific adaptive mutations in ZIKV has not been well investigated. In...

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Identifiers

PMID: 39412258
DOI: 10.1128/jvi.01251-24
PMCID: PMC11575407

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