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Article

Acetylation of histone H4 lysine 5 and 12 is required for CENP-A deposition into centromeres.

Nature communications - 4 Nov 2016

Shang Wei-Hao, Hori Tetsuya, Westhorpe Frederick G, Godek Kristina M, Toyoda Atsushi, Misu Sadahiko, Monma Norikazu, Ikeo Kazuho, Carroll Christopher W, Takami Yasunari, Fujiyama Asao, Kimura Hiroshi, Straight Aaron F, Fukagawa Tatsuo

Abstract excerpt

Centromeres are specified epigenetically through the deposition of the centromere-specific histone H3 variant CENP-A. However, how additional epigenetic features are involved in centromere specification is unknown. Here, we find that histone H4 Lys5 and Lys12 acetylation (H4K5ac and H4K12ac) primarily occur within the pre-nucleosomal CENP-A-H4-HJURP (CENP-A chaperone) complex, before centromere deposition. We...

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Identifiers

PMID: 27811920
DOI: 10.1038/ncomms13465
PMCID: PMC5097169

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HJURP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Acetylation of histone H4 lysine 5 and 12 is required for CENP-A deposition into centromeres.PMID 27811920Read ↗

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