Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of Polygenic Risk Score With Cognitive Decline and Motor Progression in Parkinson Disease.

JAMA neurology - 1 Mar 2018

Paul Kimberly C, Schulz Jessica, Bronstein Jeff M, Lill Christina M, Ritz Beate R

Abstract excerpt

Importance: Genetic factors have a well-known influence on Parkinson disease (PD) susceptibility. The largest genome-wide association study (GWAS) identified 26 independent single-nucleotide polymorphisms (SNPs) associated with PD risk. Among patients, the course and severity of symptom progression is variable, and little is known about the potential association of genetic factors with phenotypic variance....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cognition Disorders
Share to Cohort Studies
Share to Disease Progression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Motor Activity

Share to Outcome Assessment, Health Care

Share to Parkinson Disease

Share to Proportional Hazards Models

Share to Severity of Illness Index

Source

Open in PubMed Open full text

Identifiers

PMID: 29340614
DOI: 10.1001/jamaneurol.2017.4206
PMCID: PMC5885856

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of Polygenic Risk Score With Cognitive Decline and Motor Progression in Parkinson Disease.PMID 29340614Read ↗

Polygenic Risk Scores Contribute to Personalized Medicine of Parkinson’s DiseaseSemantic proximity Read ↗

A cumulative genetic risk score predicts progression in Parkinson's disease.Semantic proximity Read ↗

Genome-wide survival study identifies a novel synaptic locus and polygenic score for cognitive progression in Parkinson's disease.Semantic proximity Read ↗

Genome-wide association studies of cognitive and motor progression in Parkinson's diseaseSemantic proximity Read ↗

Progression to Parkinson's dementia is not modulated by genetic risk variants for Alzheimer's or Parkinson's disease.Semantic proximity Read ↗

An improved polygenic score for Parkinson’s disease partly explains variable penetrance of genetic Parkinson’s diseaseSemantic proximity Read ↗

Genome-Wide Polygenic Risk Score Identifies Individuals at Elevated Parkinson’s Disease RiskSemantic proximity Read ↗

Polygenic risk score-based prediction for Parkinson’s diseaseSemantic proximity Read ↗

Expanding Parkinson’s disease genetics: novel risk loci, genomic context, causal insights and heritable riskSemantic proximity Read ↗

Genetic Associations With Rapid Motor and Cognitive Deterioration in Parkinson’s DiseaseSemantic proximity Read ↗

GWAS Identifies DPP6 as Risk Gene of Cognitive Decline in Parkinson's Disease.Semantic proximity Read ↗

Association of Family History and Polygenic Risk Score With Longitudinal Prognosis in Parkinson DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.