Article

Cross-trait and multi-polytranscriptomic score analysis of Parkinson's disease identifies novel associations and improves prediction

2026-08-26

Abstract excerpt

Despite major progress in genomic risk loci identification, biological mechanisms underlying Parkinson's disease (PD) remain incompletely understood and the informativity of polygenic score (PGS)-based prediction remains modest. Poly transcriptomic scores (PTS) - the sum of an individual's observed gene expression weighted by transcriptome-wide association z -scores - combine the stability of genetics with the d...

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Literature Corpus work: 586d6ca1-b7ac-59a0-a477-a6231029e78f
DOI: 10.64898/2026.08.21.26358780

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