Cross-trait and multi-polytranscriptomic score analysis of Parkinson's disease identifies novel associations and improves prediction

Abstract excerpt

Despite major progress in genomic risk loci identification, biological mechanisms underlying Parkinson's disease (PD) remain incompletely understood and the informativity of polygenic score (PGS)-based prediction remains modest. Poly transcriptomic scores (PTS) - the sum of an individual's observed gene expression weighted by transcriptome-wide association z -scores - combine the stability of genetics with the d...

Topics

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• BRCA gene mutations in cancer
• Genetic Associations and Epidemiology
• Parkinson's Disease Mechanisms and Treatments

Identifiers and source

Literature Corpus work

586d6ca1-b7ac-59a0-a477-a6231029e78f

DOI

10.64898/2026.08.21.26358780