Article

Hepatitis B virus protein X promotes hepatocyte plasticity and survival in a differentiated human liver organoid system

2026-06-27

Abstract excerpt

<h4>Background & Aims</h4> Hepatitis B virus (HBV) drives hepatocellular carcinoma in part through the activity of its X protein (HBx), yet the mechanisms by which HBx alters hepatocyte function remain incompletely understood. Progress has been limited by the lack of relevant human models that support controlled HBx expression in mature hepatocytes. Here, we use an improved hepatocyte-like organoid (HLO) platform...

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Literature Corpus work: 1138182e-500a-5f3e-915b-5cbbf2ba80c4
DOI: 10.64898/2026.06.26.734750

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