Article

Patient-derived liver biopsy organoids enable precision alcohol-associated liver disease modeling

2025-03-25

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background & Aims</h4> Alcohol-associated liver disease (ALD) is a major cause of liver disease worldwide with scarce therapeutic options. Animal models poorly recapitulate advanced ALD precluding the development of new treatments. Organoids have emerged as a powerful human-based preclinical tool. However, current patient-derived liver organoids fail to recapitulate the epithelial heterogen...

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Literature Corpus work: 104313c9-7551-54c3-b8a2-616f395257c0
DOI: 10.1101/2025.03.22.644563

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