Article

Hepatitis C Virus Infects and Perturbs Liver Stem Cells

2021-10-26

Abstract excerpt

<h4>Summary</h4> Hepatitis C virus (HCV) is the leading cause of death from liver disease. How HCV infection causes lasting liver damage and increases cancer risk beyond viral clearance remains unclear. We identify bipotent liver stem cells as novel targets for HCV infection, and their erroneous differentiation as the potential cause of impaired liver regeneration and cancer development. We show 3D organoids gene...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 84202337-d963-538e-b9da-2a8fbeab0d9b
DOI: 10.1101/2021.10.26.465357

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hepatitis C Virus Infects and Perturbs Liver Stem CellsDOI 10.1101/2021.10.26.465357Read

Productive Hepatitis C Virus Infection of Stem Cell-Derived Hepatocytes Reveals a Critical Transition to Viral Permissiveness during DifferentiationSemantic proximity Read

Human stem cell-derived hepatocytes as a model for hepatitis B virus infection, spreading and virus-host interactionsSemantic proximity Read

A Human Liver Cell Atlas: Revealing Cell Type Heterogeneity and Adult Liver Progenitors by Single-Cell RNA-sequencingSemantic proximity Read

Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systemsSemantic proximity Read

Initial HCV infection of adult hepatocytes triggers a temporally structured transcriptional program containing diverse pro- and anti-viral elementsSemantic proximity Read

Decoding liver fibrogenesis with single-cell technologiesSemantic proximity Read

Hepatitis C virus: life cycle in cells, infection and host response, and analysis of molecular markers influencing the outcome of infection and response to therapy.Semantic proximity Read

Human Liver Organoids as a Patient-derived Model for HBV Infection and Cellular ResponseSemantic proximity Read

Hepatitis C Virus-Induced Cancer Stem Cell-Like Signatures in Cell Culture and Murine Tumor XenograftsSemantic proximity Read

Hepatitis D virus infection of stem cell-derived hepatocytes triggers an IFN- and NFκB-based innate immune response unable to clear infectionSemantic proximity Read

Human pluripotent stem cell-derived hepatocytes support complete replication of hepatitis C virusSemantic proximity Read

Turning Hepatic Cancer Stem Cells Inside Out – A Deeper Understanding through Multiple PerspectivesSemantic proximity Read