Article

Human liver organoids; a patient-derived primary model for HBV Infection and Related Hepatocellular Carcinoma

2019-03-05

Abstract excerpt

The molecular events that drive Hepatitis B virus (HBV)-mediated transformation and tumorigenesis have remained largely unclear, due to the absence of a relevant primary model system. Here we propose the use of human liver organoids as a platform for modeling HBV infection and related tumorigenesis. We first describe a primary ex vivo HBV-infection model derived from healthy donor liver organoids after challenge w...

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Literature Corpus work: 5b1268cf-bd6a-5361-9a63-4137ab29295b
DOI: 10.1101/568147

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