Article

Mass Generation and Long-term Expansion of Hepatobiliary Organoids from Adult Primary Human Hepatocytes

2024-06-11

Abstract excerpt

Adult primary human hepatocytes (PHHs) are the gold standard in ex vivo toxicological studies and possess the clinical potential to treat patients with liver disease as advanced therapy medicinal products (ATMPs). However, the utility of this valuable cell type has been limited by short-term functionality and limited expansion potential in vitro. While notable advances have been made in the long-term maintenance o...

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Literature Corpus work: f5967b67-ca1b-53b9-bab1-669f8606fbab
DOI: 10.1101/2024.06.10.598262

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