Article

Human Liver Organoids as a Patient-derived Model for HBV Infection and Cellular Response

2022-10-21

Abstract excerpt

<h4>Background & Aims</h4> Current HBV in vitro model systems suffer from many physiological limitations that restrict understanding of complex viral-host interactions and thus prohibit prediction of disease in vivo . We developed and assessed adult stem cell (AdSC) derived liver organoids as a novel model system for characterisation of the HBV lifecycle, the cellular response to infection and demonstrate their...

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Literature Corpus work: 24357029-f45e-5e78-886e-37a21506ef2e
DOI: 10.1101/2022.10.20.513112

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