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Article

Arginine methylation mediated by the Arabidopsis homolog of PRMT5 is essential for proper pre-mRNA splicing.

Proceedings of the National Academy of Sciences of the United States of America - 2 Nov 2010

Deng Xian, Gu Lianfeng, Liu Chunyan, Lu Tiancong, Lu Falong, Lu Zhike, Cui Peng, Pei Yanxi, Wang Baichen, Hu Songnian, Cao Xiaofeng

Abstract excerpt

Protein arginine methylation, one of the most abundant and important posttranslational modifications, is involved in a multitude of biological processes in eukaryotes, such as transcriptional regulation and RNA processing. Symmetric arginine dimethylation is required for snRNP biogenesis and is assumed to be essential for pre-mRNA splicing; however, except for in vitro evidence, whether it affects splicing in...

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Identifiers

PMID: 20956294
DOI: 10.1073/pnas.1009669107
PMCID: PMC2973915

Genes

PRMT5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Arginine methylation mediated by the Arabidopsis homolog of PRMT5 is essential for proper pre-mRNA splicing.PMID 20956294Read ↗

Regulation of flowering time by the protein arginine methyltransferase AtPRMT10.Semantic proximity Read ↗

A methyl transferase links the circadian clock to the regulation of alternative splicing.Semantic proximity Read ↗

Mutations in the Type II protein arginine methyltransferase AtPRMT5 result in pleiotropic developmental defects in Arabidopsis.Semantic proximity Read ↗

Arginine methylation of SM-LIKE PROTEIN 4 antagonistically affects alternative splicing during Arabidopsis stress responses.Semantic proximity Read ↗

ORRM5, an RNA recognition motif-containing protein, has a unique effect on mitochondrial RNA editing.Semantic proximity Read ↗

The enzymatic activity of Arabidopsis protein arginine methyltransferase 10 is essential for flowering time regulation.Semantic proximity Read ↗

A systematic survey of PRMT interactomes reveals key roles of arginine methylation in the global control of RNA splicing and translationSemantic proximity Read ↗

The conserved spliceosomal protein AtSF3B2 controls the floral transition by regulating transcription and splicing in Arabidopsis.Semantic proximity Read ↗

PICLN modulates alternative splicing and ensures adaptation to light and temperature changes in plantsSemantic proximity Read ↗

The RNA-binding protein HOS5 and serine/arginine-rich proteins RS40 and RS41 participate in miRNA biogenesis in Arabidopsis.Semantic proximity Read ↗

m6A demethylase OsALKBH5 is required for double-strand break formation and repair by affecting mRNA stability in rice meiosis.Semantic proximity Read ↗

Identification of alternative splicing events regulated by an Arabidopsis serine/arginine-like protein, atSR45a, in response to high-light stress using a tiling array.Semantic proximity Read ↗

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